Hydrogen Bromide → HCID 20160728, compound

HRID 247442Notes

Reaction equation

HRID 247442 reaction equation
Cl.C[O:3][C:4]1[C:5]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:6][C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:8]=2[CH:20]=1.[BrH:25]>>[BrH:25].[OH:3][C:4]1[C:5]([S:21](=[O:23])(=[O:24])[NH2:22])=[CH:6][C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:8]=2[CH:20]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 20160720HCID 20160720, compound

Product 1

HCID 20160728HCID 20160728, compound

Procedure

The sulfamoyl compound (3.7 g, 0.01 m) is suspended in 3N hydrochloric acid, heated to reflux for 16 hours and concentrated in vacuo to give 8-methoxy-1-phenyl-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride. 8-Methoxy-1-phenyl-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (3.7 g, 0.01 m) is dissolved in 48% hydrobromic acid (20 ml), refluxed for 2 hours and concentrated in vacuo to afford 8-hydroxy-1-phenyl-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Workup

  1. temperaturerefluxed for 2 hours
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4a8d5863228248d29fa7569fe6188343
Source dataset
uspto-grants-1987_11
Patent number
US04707483

Reaction notes

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