Hydrochloric Acid → HCID 20160708, compound

HRID 247446Notes

Reaction equation

HRID 247446 reaction equation
C([N:4]1[CH2:10][CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]2[CH:17]=[C:18]([S:23]([Cl:26])(=[O:25])=[O:24])[C:19]([O:21][CH3:22])=[CH:20][C:7]=2[CH2:6][CH2:5]1)(=O)C.[OH-].[NH4+:28].Cl>>[ClH:26].[CH3:22][O:21][C:19]1[C:18]([S:23](=[O:25])(=[O:24])[NH2:28])=[CH:17][C:8]2[CH:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:10][NH:4][CH2:5][CH2:6][C:7]=2[CH:20]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 20160730HCID 20160730, compound

Product 1

HCID 20160708HCID 20160708, compound

Procedure

By the procedure of Example 2, 3-acetyl-8-chlorosulfonyl-7-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine is treated with ammonium hydroxide followed by hydrochloric acid to give 7-methoxy-1-phenyl-8-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride.

Sources & evidence

ORD record
ord-714f9cc459d142979c783089d1b37b41
Source dataset
uspto-grants-1987_11
Patent number
US04707483

Reaction notes

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