反应详情

2.6 g of indole and 8.6 g of N,N-dimethylanisamide were added to 2.6 ml of phosphorus oxychloride. The mixture was heated at 80°-85° C. for 3 hours. After cooling,50 ml of ether was added to the mixture. The reaction mixture was then poured into water and pH value was adjusted to 10 with aqueous solution of sodium hydroxide. The resulting precipitate was filtered out and then recrystallized from ethanol to obtain compound 1 in the form of white crystals. (Yield: 56%)

1. temperatureThe mixture was heated at 80°-85° C. for 3 hours
2. temperatureAfter cooling
3. filtrationThe resulting precipitate was filtered out
4. customrecrystallized from ethanol