Ethyl formate → HCID 178522216, compound

HRID 24759Notes

Reaction equation

HRID 24759 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]/[C:9](=[C:16]2\[C:17](=[O:25])[NH:18][C:19]3[C:24]\2=[CH:23][CH:22]=[CH:21][CH:20]=3)/[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH:26](OCC)=[O:27]>CN(C=O)C>[CH:26]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]/[C:9](=[C:16]2\[C:17](=[O:25])[NH:18][C:19]3[C:24]\2=[CH:23][CH:22]=[CH:21][CH:20]=3)/[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1)=[O:27]

Participants

4

Reactant 2

HCID 8025Ethyl formateHCID 178507732HCID 178507732, compound

Product 1

HCID 178522216HCID 178522216, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

200 mg (0.6 mmol) of (Z)-3-[1-(4-aminophenylamino)-1-phenyl-methylidene]-2-indolinone and 5 ml of ethyl formate are stirred in 2.5 ml of DMF for 60 hours at 90° C. After removal of the solvent in vacuo ethyl acetate is added and the mixture is again concentrated by evaporation. The residue is stirred with ether, suction filtered and dried.

Workup

  1. customAfter removal of the solvent in vacuo ethyl acetate
  2. additionis added
  3. concentrationthe mixture is again concentrated by evaporation
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-84077a15d7984efd82434c9bbf6b0b42
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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