N-(4-Aminophenyl)propanamide → HCID 178460035, compound

HRID 24769Notes

Reaction equation

HRID 24769 reaction equation
C(O[C:4](=[C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][C:12]1=[O:20])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)C.[C:21]([NH:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=1)(=[O:24])[CH2:22][CH3:23]>CN(C=O)C.O>[C:21]([NH:25][C:26]1[CH:32]=[CH:31][C:29]([NH:30]/[C:4](=[C:11]2\[C:12](=[O:20])[NH:13][C:14]3[C:19]\2=[CH:18][CH:17]=[CH:16][CH:15]=3)/[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)=[CH:28][CH:27]=1)(=[O:24])[CH2:22][CH3:23]

Participants

5

Reactant 2

HCID 314342N-(4-Aminophenyl)propanamideHCID 540376233-(1-Ethoxy-1-phenyl-methylidene)-2-indolinone

Product 1

HCID 178460035HCID 178460035, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

265 mg (1 mmol) of 3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone are dissolved in 5 ml of DMF and after the addition of 300 mg (1.8 mmol) of 4-propionylamino-aniline stirred for 8 hours at 150° C. After cooling, it is diluted with water, the crystalline product is suction filtered, washed and dried.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-46821cce08f7485c9c9fe6008bf62fa5
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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