反应详情

A mixture of diphenylmethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(Z)-1-butenyl]-3-cephem-4-carboxylate (1.65 g, 2.65 mmoles) and anisole (0.5 ml) was treated with TFA (5 ml) at room temperature for 1 hour. The mixture was diluted with IPE. The resulting precipitate*1 was collected by filtration and chromatographed on a column of the packing (50 ml) of a PrepPAK cartridge (Waters) with 20-30% methanol to yield 605 mg (52%) of the title compound. Estimated purity 90% (by HPLC). Mp.>160° C. (grad. dec.).

1. additionThe mixture was diluted with IPE
2. filtrationThe resulting precipitate*1 was collected by filtration
3. customchromatographed on a column of the packing (50 ml) of a PrepPAK cartridge (Waters) with 20-30% methanol