Sodium Hydroxide → HCID 178485766, compound

HRID 24776Notes

Reaction equation

HRID 24776 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](OCC)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[N:24]1([CH2:30][C:31]([N:33]([C:35]2[CH:41]=[CH:40][C:38]([NH2:39])=[CH:37][CH:36]=2)[CH3:34])=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1.[OH-].[Na+]>CN(C=O)C.CO>[N:24]1([CH2:30][C:31]([N:33]([C:35]2[CH:36]=[CH:37][C:38]([NH:39]/[C:13](=[C:6]3\[C:5](=[O:23])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[CH:10][CH:11]=4)/[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:40][CH:41]=2)[CH3:34])=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 225696444-(N-piperidinomethylcarbonyl-N-methyl-amino)-anilineHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 178485766HCID 178485766, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 43 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and 4-(N-piperidinomethylcarbonyl-N-methyl-amino)-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-270be165663e40eba849d19aa046c37a
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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