Methyl Bromide → 1-Methyl-3-(2-amino-thiazol-4-yl)pyridinium bromide

HRID 247770Notes

Reaction equation

HRID 247770 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[N:6]=1.[Br:13][CH3:14]>C(#N)C>[Br-:13].[CH3:14][N+:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:5]2[N:6]=[C:2]([NH2:1])[S:3][CH:4]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 6323Methyl BromideHCID 1548934-(3-Pyridinyl)-2-thiazolamine

Product 1

HCID 145101791-Methyl-3-(2-amino-thiazol-4-yl)pyridinium bromide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of 3-(2-amino-thiazol-4-yl)pyridine (12.84 g) in acetonitrile (450 ml) containing bromomethane (6.84 g) was heated in stirring autoclave at 90° C. for 20 h.

Workup

  1. temperaturewas heated

Sources & evidence

ORD record
ord-6c57e80210b040309ed1fe60593baed2
Source dataset
uspto-grants-1993_05
Patent number
USRE034242

Reaction notes

Loading…