Triethylamine → HCID 178485827, compound

HRID 247816Notes

Reaction equation

HRID 247816 reaction equation
[C:1]([C:5]1[NH:6][NH:7][C:8](=[O:10])[N:9]=1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:18][N:19]=[C:20]=[O:21]>O1CCCC1>[C:1]([C:5]1[N:9]=[C:8]([OH:10])[N:7]([C:20](=[O:21])[NH:19][CH3:18])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 178441881HCID 178441881, compound

Product 1

HCID 178485827HCID 178485827, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of 1.41 g (0.01 mole) of 3-tert-butyl-1H-1,2,4-triazole-5-one and 0.5 g of triethylamine was added 50 ml of tetrahydrofuran, to the mixture was added 2.28 g (0.04 mole) of methylisocyanate while stirring, and the reaction was carried out at 60° C. for 2 hours. By concentration of the reaction mixture under a reduced pressure a white powder was obtained, which was washed with n-hexane to give 1.6 g of white powder of 3-tert-butyl-1-N-methylcarbamoyl-5-hydroxy-1,2,4-triazole. (yield 81%)

Workup

  1. customBy concentration of the reaction mixture under a reduced pressure a white powder was obtained
  2. washwhich was washed with n-hexane

Sources & evidence

ORD record
ord-bedc6526ae7348059bf7e9ecd40e43aa
Source dataset
uspto-grants-1993_05
Patent number
US05208231

Reaction notes

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