Sodium Hydroxide → 3-{1-[N-(4-cyanophenyl)-N-methyl-amino]-1-phenyl-methylidene}-2-indolinone

HRID 24786Notes

Reaction equation

HRID 24786 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](Cl)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:21])(=O)C.[CH3:22][NH:23][C:24]1[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[CH:26][CH:25]=1.[OH-].[Na+]>C1COCC1.CO>[C:28]([C:27]1[CH:30]=[CH:31][C:24]([N:23]([C:13](=[C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[NH:4][C:5]2=[O:21])[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH3:22])=[CH:25][CH:26]=1)#[N:29]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 109645514-(Methylamino)benzonitrileHCID 697436571-Acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone

Product 1

HCID 697403903-{1-[N-(4-cyanophenyl)-N-methyl-amino]-1-phenyl-methylidene}-2-indolinone

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 2 from 1-acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone and 4-methylamino-benzonitrile in THF and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-13797840b9b6404692a82f9251408b5f
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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