反应详情

A mixture of 0.75 g of product from Example 5, 0.412 g of benzyl bromide and 3 ml of acetonitrile is stirred at room temperature for 17.5 hours then heated, in a sealed tube, at 100° C. for 21.25 hours. The cooled reaction mixture is concentrated in vacuo and the residue purified by column chromatography (silica gel: 10% methyl alcohol/chloroform) to give 0.515 g of the desired product.

1. temperaturethen heated, in a sealed tube, at 100° C. for 21.25 hours
2. customThe cooled reaction mixture
3. concentrationis concentrated in vacuo
4. customthe residue purified by column chromatography (silica gel: 10% methyl alcohol/chloroform)