反应详情

A mixture of 100.0 g of 3-chloro-4-(hydroxy)benzoic acid methyl ester, 148.6 g of 1-bromotetradecane, 170.4 g of potassium carbonate and 1 L of acetone is heated at reflux temperature for 40.5 hours. The cooled reaction is filtered, concentrated in vacuo and purified by column chromatography (silica gel:0-2% ethyl acetate/hexane) to give 197.1 g of the desired product as colorless crystals.

1. temperatureis heated
2. temperatureat reflux temperature for 40.5 hours
3. customThe cooled reaction
4. filtrationis filtered
5. concentrationconcentrated in vacuo
6. custompurified by column chromatography (silica gel:0-2% ethyl acetate/hexane)