反应详情

A mixture of 45 g of product from Example 40, 51.2 g of finely powdered potassium carbonate, 72 g of 1-bromotetradecane, 1.9 g of sodium iodide and 500 ml of 2-butanone is heated at reflux temperature for 18 hours under an atmosphere of argon. The reaction is cooled and filtered. The filtrate is concentrated in vacuo and the residue is dissolved in chloroform. The organic layer is washed with 1N sodium hydroxide and saturated sodium chloride, dried and concentrated in vacuo. The residue is recrystallized from hexane to give 66.4 g of the desired product as white crystals.

1. temperatureis heated
2. temperatureat reflux temperature for 18 hours under an atmosphere of argon
3. temperatureThe reaction is cooled
4. filtrationfiltered
5. concentrationThe filtrate is concentrated in vacuo
6. dissolutionthe residue is dissolved in chloroform
7. washThe organic layer is washed with 1N sodium hydroxide and saturated sodium chloride
8. customdried
9. concentrationconcentrated in vacuo
10. customThe residue is recrystallized from hexane