反应详情

A mixture of 23.0 g of product from Example 60, 34.6 g of 1-bromotetradecane, 54.6 g of potassium carbonate and 250 ml of acetone is heated at reflux temperature for 48 hours. The cooled reaction is filtered and concentrated in vacuo. The residue is purified by column chromatography (silica gel:0-4.5% ethyl acetate/hexane) to give 46.3 g of the desired product as colorless prisms.

1. temperatureis heated
2. temperatureat reflux temperature for 48 hours
3. customThe cooled reaction
4. filtrationis filtered
5. concentrationconcentrated in vacuo
6. customThe residue is purified by column chromatography (silica gel:0-4.5% ethyl acetate/hexane)