反应详情

A mixture of 23 g of product from Example 84, 13.15 g of methyl bromoacetate, 10.45 g of potassium carbonate and 200 ml of acetone is heated at reflux for 24 hours. The reaction is cooled, chloroform added, filtered and concentrated. The residue is recrystallized from hexane to give 25 g of the desired product as a white solid.

1. temperatureis heated
2. temperatureat reflux for 24 hours
3. temperatureThe reaction is cooled
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue is recrystallized from hexane