HRID248034

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID289830

N-(4-Pyridinylmethyl)acetamide

C8H10N2O

结构：CCCCCCCCCCCCCCOc1ccc(C(=O)Cl)cc1C(C)(C)C

HCID19015370

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccncc2)C(C)=O)cc1C(C)(C)C

HCID10481861

未命名化合物

收率 8.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The title compound is prepared by the procedure of Example 27, using 0.90 g of product from Example 15, 0.316 g of washed 50% sodium hydride, 2.57 g of product from Example 33 and 25 ml of dry tetrahydrofuran. The residue is purified by chromatography (silica gel: 40% ethyl acetate/hexane) to give 0.275 g of desired product as a yellow oil which crystallizes on standing.

WORKUP

后处理

customThe title compound is prepared by the procedure of Example 27
customThe residue is purified by chromatography (silica gel: 40% ethyl acetate/hexane)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f527098ab3e34e48b20a48bd46ed9fb7
来源数据集: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05208247
来源说明: uspto-grants-1993_05

反应 SMILES

[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9](=[O:11])[CH3:10])=[CH:3][CH:2]=1.[H-].[Na+].[CH3:14][C:15]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=1[O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[C:21](Cl)=[O:22])([CH3:17])[CH3:16]>O1CCCC1>[C:9]([N:8]([CH2:7][C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1)[C:21](=[O:22])[C:20]1[CH:24]=[CH:25][C:26]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])=[C:18]([C:15]([CH3:17])([CH3:16])[CH3:14])[CH:19]=1)(=[O:11])[CH3:10]