1-Iodopropane → HCID 73653193, compound

HRID 248135Notes

Reaction equation

HRID 248135 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:10][OH:11])[CH:2]=1.[I:18][CH2:19][CH2:20][CH3:21]>C(#N)C>[I-:18].[OH:11][N:10]=[C:9]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[CH2:8][CH2:7][C:3]1[CH:2]=[N+:1]([CH2:19][CH2:20][CH3:21])[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 336431-IodopropaneHCID 73455022HCID 73455022, compound

Product 1

HCID 73653193HCID 73653193, compoundYield 101.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 3-(3-pyridinyl)-1-phenylpropan-1-one oxime (4.79 g, 0.021 mol) in acetonitrile (50 mL) was added 1-iodopropane (3.10 mL, 0.032 mol). The mixture was then refluxed for 12 hours. Solvent was removed to dryness under vacuum to give a dark brown oil (8.46 g, 100%). The crude product was used in the next step without further purification.

Workup

  1. temperatureThe mixture was then refluxed for 12 hours
  2. customSolvent was removed to dryness under vacuum

Sources & evidence

ORD record
ord-b6b7787d5dcb4a6e8b1fb6d36f89545d
Source dataset
uspto-grants-1993_05
Patent number
US05208343

Reaction notes

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