Toluene → HCID 178439713, compound

HRID 248310Notes

Reaction equation

HRID 248310 reaction equation
[F:1][C:2]([F:12])([F:11])[C@H:3]1[CH2:8][CH2:7][C@H:6]([CH:9]=[O:10])[CH2:5][CH2:4]1.[CH2:13]([CH:16]([CH3:20])[CH:17](O)[OH:18])[CH2:14][CH3:15].C1(C)C=CC=CC=1.CC1C=CC(S(O)(=O)=O)=CC=1>O>[F:1][C:2]([F:11])([F:12])[C@H:3]1[CH2:4][CH2:5][C@H:6]([CH:9]2[O:18][CH2:17][CH:16]([CH2:13][CH2:14][CH3:15])[CH2:20][O:10]2)[CH2:7][CH2:8]1

Participants

6

Reactant 4

HCID 1140TolueneHCID 6101p-Toluenesulfonic acidHCID 219438382-PropylpropanediolHCID 178520943HCID 178520943, compound

Product 1

HCID 178439713HCID 178439713, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 0.02 mol of trans-4-trifluoromethyl-1-formylcyclohexane (prepared as in Example 3), 0.02 mol of 2-propylpropanediol, 30 ml of toluene and 0.5 g of pTsOH (sic) is heated for 4 hours on a water separator. The pure product is obtained after customary work-up and crystallization.

Workup

  1. customThe pure product is obtained
  2. customafter customary work-up and crystallization

Sources & evidence

ORD record
ord-08f48b11c11f42c2b6f50a89daae7568
Source dataset
uspto-grants-1993_05
Patent number
US05209868

Reaction notes

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