Hydrochloric Acid → HCID 15670189, compound

HRID 248679Notes

Reaction equation

HRID 248679 reaction equation
[Na+].[C:2]([S:5][CH2:6][CH:7]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)[C:8]([NH:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([O-:16])=[O:15])=[O:9])(=[O:4])[CH3:3].Cl>O>[C:2]([S:5][CH2:6][CH:7]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=1)[C:8]([NH:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([OH:16])=[O:15])=[O:9])(=[O:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23701009HCID 23701009, compound

Product 1

HCID 15670189HCID 15670189, compoundYield 84.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-[[2-Acetylthiomethyl-3-(4-fluorophenyl)-propionyl]amino]benzoic acid sodium salt (compound of Example 40) (0.5 g) is dissolved in water (10 ml), and the mixture is adjusted to pH 2.5 with 1 N hydrochloric acid with stirring under ice cooling, and the mixture is extracted with ethyl acetate (20 ml). The extract is washed with water and dried over anhydrous magnesium sulfate, and then ethyl acetate is distilled off to give the title compound (0.4 g).

Workup

  1. extractionthe mixture is extracted with ethyl acetate (20 ml)
  2. washThe extract is washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationethyl acetate is distilled off

Sources & evidence

ORD record
ord-d260fdbfa0cc465eb22b88d999d322bd
Source dataset
uspto-grants-1993_05
Patent number
US05210266

Reaction notes

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