Phenoxyethanol → HCID 15670239, compound

HRID 248698Notes

Reaction equation

HRID 248698 reaction equation
[C:1]([S:4][CH2:5][CH:6]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:7]([NH:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([O:15][CH2:16][C:17]#N)=[O:14])=[O:8])(=[O:3])[CH3:2].[O:29](CCO)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>CN(C)C1C=CN=CC=1.C(N(CC)CC)C>[C:1]([S:4][CH2:5][CH:6]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:7]([NH:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([O:15][CH2:16][CH2:17][O:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:14])=[O:8])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 31236PhenoxyethanolHCID 15670238HCID 15670238, compound

Product 1

HCID 15670239HCID 15670239, compoundYield 51.9%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 8471TriethylamineSolvent

Conditions

Temperature
60 °C

Procedure

Cyanomethyl 3-[(2 acetylthiomethyl-3-phenylpropionyl)amino]benzoate (compound of Example 116) (4 g), 2-phenoxyethanol (3 g), 4-dimethylaminopyridine (0.1 g) and triethylamine (2 g) are mixed, and the mixture is stirred at 60° C. for 15 hours and extracted with ethyl acetate (50 ml). The extract is washed with 10% hydrochloric acid and water, and ethyl acetate is distilled off under reduced pressure. The residue is dissolved in 50% aqueous acetonitrile and purified by a column chromatography using Diaion HP-20 (eluant, water-acetonitrile). The fractions containing the desired compound are collected, and acetonitrile is distilled off under reduced pressure. The aqueous solution is extracted with ethyl acetate (100 ml). The extract is dried over anhydrous magnesium sulfate, and ethyl acetate is distilled off under reduced pressure to give the title compound (2.5 g).

Workup

  1. extractionextracted with ethyl acetate (50 ml)
  2. washThe extract is washed with 10% hydrochloric acid and water, and ethyl acetate
  3. distillationis distilled off under reduced pressure
  4. dissolutionThe residue is dissolved in 50% aqueous acetonitrile
  5. custompurified by a column chromatography
  6. additionThe fractions containing the desired compound
  7. customare collected
  8. distillationacetonitrile is distilled off under reduced pressure
  9. extractionThe aqueous solution is extracted with ethyl acetate (100 ml)
  10. dry with materialThe extract is dried over anhydrous magnesium sulfate, and ethyl acetate
  11. distillationis distilled off under reduced pressure

Sources & evidence

ORD record
ord-a9bfba8f528c4d658a91749fd406923a
Source dataset
uspto-grants-1993_05
Patent number
US05210266

Reaction notes

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