Piperidine → HCID 178505110, compound

HRID 24887Notes

Reaction equation

HRID 24887 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](OCC)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[O:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][N:32]([C:37]2[CH:43]=[CH:42][C:40]([NH2:41])=[CH:39][CH:38]=2)[S:33]([CH3:36])(=[O:35])=[O:34])[CH2:26][CH2:25]1.N1CCCCC1>CN(C=O)C.CO>[O:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][N:32]([C:37]2[CH:43]=[CH:42][C:40]([NH:41]/[C:13](=[C:6]3\[C:5](=[O:23])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[CH:10][CH:11]=4)/[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:39][CH:38]=2)[S:33]([CH3:36])(=[O:35])=[O:34])[CH2:26][CH2:25]1

Participants

6

Reactant 3

HCID 8082PiperidineHCID 22569549HCID 22569549, compoundHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 178505110HCID 178505110, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Examples 1 and 187 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and 4-[N-(2-morpholinoethyl)-N-methylsulphonyl-amino]-aniline in DMF and subsequent treatment with piperidine in methanol.

Sources & evidence

ORD record
ord-23f528af73ba4ef894b9c4aaffd2ac96
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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