反应详情

Trifluoroiodomethane (2.3 g) was cooled to -78° C. with a trap. DMF (7 ml), (2S)-1-[3-(N-benzyl-N-methylcarbamoyl)propanoyl]pyrrolidin-2-al (710 mg) and zinc (1.0 g) were added there to. And the mixture was treated with ultrasonic waves for 2 hrs. at room temperature. 1N hydrochloric acid was added to the reaction solution. The mixture was extracted with EtOAc. The extract was washed, dried, and evaporated. The residue was purified by column chromatography on silica gel (hexane-EtOAc) to give the title compound (217 mg) having the following physical data:

1. additionAnd the mixture was treated with ultrasonic waves for 2 hrs
2. customat room temperature
3. extractionThe mixture was extracted with EtOAc
4. washThe extract was washed
5. customdried
6. customevaporated
7. customThe residue was purified by column chromatography on silica gel (hexane-EtOAc)