Piperidine → HCID 178505111, compound

HRID 24897Notes

Reaction equation

HRID 24897 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[C:6](=[C:16](OCC)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]1=[O:26])(=O)C.[O:27]1[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][N:35]([C:40]2[CH:46]=[CH:45][C:43]([NH2:44])=[CH:42][CH:41]=2)[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:29][CH2:28]1.N1CCCCC1>CN(C=O)C.CO>[O:27]1[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][N:35]([C:40]2[CH:46]=[CH:45][C:43]([NH:44]/[C:16](=[C:6]3\[C:5](=[O:26])[NH:4][C:12]4[C:7]\3=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=4)/[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:42][CH:41]=2)[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:29][CH2:28]1

Participants

6

Reactant 3

HCID 8082PiperidineHCID 22569549HCID 22569549, compoundHCID 542801041-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone

Product 1

HCID 178505111HCID 178505111, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Examples 1 and 187 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 4-[N-(2-morpholinoethyl)-N-methylsulphonyl-amino]-aniline in DMF and subsequent treatment with piperidine in methanol.

Sources & evidence

ORD record
ord-cc7a7f10e7224370b544d6f69ffb86c4
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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