1,1'-Carbonyldiimidazole → HCID 178483435, compound

HRID 248971Notes

Reaction equation

HRID 248971 reaction equation
[CH3:1][N:2]([CH2:11][CH2:12][CH:13]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH2:10].[C:26](N1C=CN=C1)(N1C=CN=C1)=[O:27].[NH:38]([C:42]1[S:43][CH:44]=[C:45]([CH2:47][S:48][CH2:49][CH2:50][NH2:51])[N:46]=1)[C:39]([NH2:41])=[NH:40]>C(Cl)Cl>[NH:38]([C:42]1[S:43][CH:44]=[C:45]([CH2:47][S:48][CH2:49][CH2:50][NH:51][C:26]([NH:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][N:2]([CH2:11][CH2:12][CH:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH3:1])=[O:27])[N:46]=1)[C:39]([NH2:41])=[NH:40]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 19762534HCID 19762534, compoundHCID 1785127232-[4-(2-Aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine

Product 1

HCID 178483435HCID 178483435, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Preparation is effected analogously to Example 63, using 0.85 g (2.5 mmol) of N-methyl-N-[3-phenyl-3-(2-pyridyl)propyl]-1,7-heptanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.65 g (2.8 mmol) of 2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethaneamine as starting materials. Working up by chromatography (eluant: methylene chloride) analogously to Example 63 yields the purified title compound in the form of an oil; MS (+FAB method): m/z (rel. int.[%])=597 ([M+H]+, 7), 196 (100); IR (KBr): 1655 cm-1 (C=O).

Workup

  1. customPreparation
  2. custompurified title compound in the form of an oil

Sources & evidence

ORD record
ord-f020ddd98ee0415b922fb3e775d9f3fc
Source dataset
uspto-grants-1993_05
Patent number
US05212187

Reaction notes

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