Hydrochloric Acid → HCID 19024862, compound

HRID 249147Notes

Reaction equation

HRID 249147 reaction equation
[BH4-].[Na+].[CH3:3][C:4]([CH3:18])([CH3:17])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:9][CH:8]=1)=[O:6].Cl>C(O)(C)C>[CH3:3][C:4]([CH3:17])([CH3:18])[CH:5]([C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH:14]([CH3:15])[CH3:16])=[CH:11][CH:12]=1)[OH:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 10560796HCID 10560796, compound

Product 1

HCID 19024862HCID 19024862, compoundYield 94.3%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
50 °C

Procedure

Sodium borohydride (4.72 g) was added to a solution of 2,2-dimethyl-4'-isobutylpropiophenone (22.7 g) in isopropyl alcohol (150 ml). The mixture was stirred at 50° C. for 2 hours and poured into ice water. After acidified with 6N-hydrochloric acid, the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate and evaporated to give 2,2-dimethyl-1-(4-isobutylphenyl)propanol as a colourless oil (21.6 g).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-b8a574c134a94e0ea4289589d97c934a
Source dataset
uspto-grants-1993_05
Patent number
US05212320

Reaction notes

Loading…