反应详情

温度

25 °C

A mixture of methyl 3-hydroxybenzoate (939 mg), 1-(1-bromoethyl)-3-isobutylbenzene (1.49 g) and potassium carbonate (1.71 g) in N,N-dimethylformamide (20 ml) was stirred at 25° C. overnight. The mixture was partitioned between ether and 1N hydrochloric acid. The organic layer was separated, washed with water and brine, dried over magnesium sulfate, and evaporated. The residue was chromatographed on silica gel (30 g) eluting with a mixture of ethyl acetate and hexane (1:10) to give methyl 3-[1-(3-isobutylphenyl)ethyl]benzoate (1.45 g) as an oil.

1. customThe mixture was partitioned between ether and 1N hydrochloric acid
2. customThe organic layer was separated
3. washwashed with water and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customThe residue was chromatographed on silica gel (30 g)
7. washeluting with a mixture of ethyl acetate and hexane (1:10)