反应详情

温度

25 °C

A mixture of 4-[3-(3-aminobenzoyl)indol-1-yl]butyric acid (880 mg), bis(4-isobutylphenyl)methyl chloride (1.03 g) and diisopropylethylamine (0.945 g) in dichloromethane (20 ml) was stirred at 25° C. overnight, and bis(4-isobutylphenyl)methyl chloride (170 mg) and diisopropylethylamine (86 mg) were added thereto. After stirring at 25° C. for 3 hours, the reaction mixture was poured into cold 1N hydrochloric acid. The organic layer was separated, washed with water, and dried over magnesium sulfate. After evaporation of the solvent, the residue was chromatographed on silica gel (100 g) with a mixture of chloroform and methanol (50:1) as eluent and freeze-dried from benzene to give 4-[3-[3-(bis[4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid (820 mg) as pale yellow powder.

1. stirringAfter stirring at 25° C. for 3 hours
2. customThe organic layer was separated
3. washwashed with water
4. dry with materialdried over magnesium sulfate
5. customAfter evaporation of the solvent
6. customthe residue was chromatographed on silica gel (100 g) with a mixture of chloroform and methanol (50:1) as eluent
7. dry with materialfreeze-dried from benzene