HRID249182

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)Cc1ccc(C(Nc2cccc(C(=O)c3cn(CCCC(=O)O)c4ccccc34)c2)c2ccc(CC(C)C)cc2)cc1

HCID178077

FK 143

C40H44N2O3

PRODUCTS

生成物

结构：CC(C)Cc1ccc(C(Nc2cccc(C(=O)c3cn(CCCC(=O)O)c4ccccc34)c2)c2ccc(CC(C)C)cc2)cc1.Cl

HCID67693235

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

A solution of 4N-hydrogen chloride (1.5 ml) in ethyl acetate was added to a solution of 4-[3-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid (3.0 g) in ethyl acetate (15 ml). The mixture was refrigerated for 16 hours to give 4-[3-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid hydrochloride as yellow crystals (3.1 g).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d7d30f36c50048d0af91d2319e19cf89
来源数据集: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05212320
来源说明: uspto-grants-1993_05

反应 SMILES

[ClH:1].[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH:12]([NH:23][C:24]2[CH:25]=[C:26]([CH:44]=[CH:45][CH:46]=2)[C:27]([C:29]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[N:31]([CH2:38][CH2:39][CH2:40][C:41]([OH:43])=[O:42])[CH:30]=2)=[O:28])[C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([CH3:22])[CH3:21])=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]>C(OCC)(=O)C>[ClH:1].[CH2:19]([C:16]1[CH:17]=[CH:18][C:13]([CH:12]([NH:23][C:24]2[CH:25]=[C:26]([CH:44]=[CH:45][CH:46]=2)[C:27]([C:29]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[N:31]([CH2:38][CH2:39][CH2:40][C:41]([OH:43])=[O:42])[CH:30]=2)=[O:28])[C:9]2[CH:8]=[CH:7][C:6]([CH2:2][CH:3]([CH3:5])[CH3:4])=[CH:11][CH:10]=2)=[CH:14][CH:15]=1)[CH:20]([CH3:21])[CH3:22]