Sodium Bicarbonate → HCID 10645969, compound

HRID 249245Notes

Reaction equation

HRID 249245 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH2:15][N:16]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])[CH2:18][CH2:17]1)[CH3:2].C([O-])(O)=O.[Na+]>C(O)(=O)C>[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH2:15][N:16]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[CH:11]=[CH:10][CH:9]=[CH:14]2)[CH2:18][CH2:17]1)[CH3:2]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 19760870HCID 19760870, compound

Product 1

HCID 10645969HCID 10645969, compoundYield 188.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2.98 g (8 mmol) of 1-(2-ethoxyethyl)-2-{4-(4-aminobutyl)homopiperazin-1-yl-methyl}benzimidazole and 1.06 g (8 mmol) of 2,5-dimethoxytetrahydrofuran hydrofuran in 30 ml of acetic acid is refluxed for 25 minutes. The mixture is cooled, poured into ice cold water, neutralised with NaHCO3 and extracted with chloroform. It is dried using Na2SO4 and evaporated to dryness under vacuum. 3.2 g of the crude compound are thus obtained which are purified on a silica chromatography column (eluent: chloroform-methanol 92:8). Yield 51%.

Workup

  1. temperatureThe mixture is cooled
  2. additionpoured into ice cold water
  3. extractionextracted with chloroform
  4. customIt is dried
  5. customevaporated to dryness under vacuum

Sources & evidence

ORD record
ord-e355372539f4438baf0e94a64cd9ce9a
Source dataset
uspto-grants-1993_05
Patent number
US05214040

Reaction notes

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