反应详情

1-Bromo-4-N-phthalimido-2-butanone (50.0 g 0.169 mol) and thiourea (25.71 g, 0.338 mol) were mixed with n-propanol (1000 ml) and concentrated hydrochloric acid (100 ml), and the reaction mixture was heated to reflux for 1.5 hour. After cooling, the precipitate was filtered and washed with n-propanol and ether. After air drying, the title product was obtained as a fluffy white solid (37.51 g, 0.121 mol, 72% yield), m.p. 230°-240° (decomp.).

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 1.5 hour
3. temperatureAfter cooling
4. filtrationthe precipitate was filtered
5. washwashed with n-propanol and ether
6. customAfter air drying