HRID24941

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5238

Sodium Iodide

INa

HCID7901

Ethanamine, 2-chloro-N,N-dimethyl-

C4H10ClN

HCID11430

Potassium Carbonate

CK2O3

$结构：CC(C)S(=O)(=O)Nc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1$

HCID178461067

未命名化合物

PRODUCTS

生成物

$结构：CC(C)S(=O)(=O)N(CCN(C)C)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1$

HCID178461075

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Prepared analogously to Example 36 from (Z)-3-{1-[4-(isopropylsulphonylamino)-phenylamino]-1-phenyl-methylidene}-2-indolinone, 1-chloro-2-dimethylamino-ethane, potassium carbonate and sodium iodide in acetone.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cc02e279fcfa414bbc246d711233f1de
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

[CH:1]([S:4]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14]/[C:15](=[C:22]2\[C:23](=[O:31])[NH:24][C:25]3[C:30]\2=[CH:29][CH:28]=[CH:27][CH:26]=3)/[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:10][CH:9]=1)(=[O:6])=[O:5])([CH3:3])[CH3:2].Cl[CH2:33][CH2:34][N:35]([CH3:37])[CH3:36].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CC(C)=O>[CH3:36][N:35]([CH3:37])[CH2:34][CH2:33][N:7]([C:8]1[CH:9]=[CH:10][C:11]([NH:14]/[C:15](=[C:22]2\[C:23](=[O:31])[NH:24][C:25]3[C:30]\2=[CH:29][CH:28]=[CH:27][CH:26]=3)/[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12][CH:13]=1)[S:4]([CH:1]([CH3:3])[CH3:2])(=[O:5])=[O:6]