Hydrochloric Acid → HCID 22569398, compound

HRID 24942Notes

Reaction equation

HRID 24942 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][N:12]([CH3:16])[CH2:13][CH2:14][NH2:15].Cl>C(O)C>[CH3:11][N:12]([CH3:16])[CH2:13][CH2:14][NH:15][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 9590p-FluoronitrobenzeneHCID 66053N,N-Dimethylethylenediamine

Product 1

HCID 22569398HCID 22569398, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.2 ml of (20 mmol) of 4-fluoronitrobenzene and 2.6 ml (24 mmol) of N,N-dimethylethylene-diamine are heated in 10 ml of ethanol at 120° C. in a microwave oven for 1.5 hours. Then 50 ml of 1 N hydrochloric acid are added. The reaction solution is washed with ethyl acetate. Then the aqueous phase is combined with 4 N sodium hydroxide solution until an alkaline reaction is obtained and extracted with ethyl acetate.

Workup

  1. washThe reaction solution is washed with ethyl acetate
  2. customThen the aqueous phase is combined with 4 N sodium hydroxide solution until an alkaline reaction
  3. customis obtained
  4. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-33970417aed54766919fad76ccaaf316
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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