Hydrochloric Acid → HCID 131728604, compound

HRID 249631Notes

Reaction equation

HRID 249631 reaction equation
[NH2:1][C:2]([NH2:4])=[NH:3].[ClH:5]>O1CCOCC1>[ClH:5].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1].[NH2:3][C:2]([NH2:4])=[NH2+:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3520Guanidine

Product 1

HCID 131728604HCID 131728604, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound 46 was prepared using General Procedure F, using the Boc-protected dendrimer guanidine 45 (0.31 g, 78.6 mmol) in 2N HCl in dioxane (10 mL). The nona-guanidinium HCl salt (46) was obtained in 91% (0.18 g) yield as a colorless hygroscopic solid. 1H NMR (CD3OD): δ 8.62 (s, 1H, ArH), 8.54 (s, 2H, ArH), 3.65 (m, 42H, CH2O and CH2NHCO), 3.33 (m, 36H, CH2NHCO and CH2NH), 2.60 (m, 6H, CH2CO), 2.44 (m, 26H, CH2CO); 13C NMR (CD3OD): δ 174.62, 173.65, 168.00, 158.55, 136.12, 131.74, 130.20, 70.00, 68.45, 61.56, 41.94, 39.57, 38.11, 37.39, 34.79: ESI-MS m/z 2138 [M+H]+, 2172 [M−Cl]+.

Workup

  1. customThe compound 46 was prepared

Sources & evidence

ORD record
ord-d6ea9ac7a159453fb3152621f5a60b59
Source dataset
uspto-grants-2011_01
Patent number
US07862807B2

Reaction notes

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