Phenylhydrazine → HCID 178515196, compound

HRID 249674Notes

Reaction equation

HRID 249674 reaction equation
[C:1]1([N:7]2[C:19](=[O:20])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC1C2C(=CC=C([F:32])C=2)N=CC=1C(OCC)=O.C1(NN)C=CC=CC=1>>[F:32][C:16]1[CH:15]=[CH:14][C:13]2[NH:12][CH:11]=[C:10]3[C:19](=[O:20])[N:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:8]=[C:9]3[C:18]=2[CH:17]=1

Participants

4

Reactant 3

HCID 7516PhenylhydrazineHCID 1479088Ethyl 4-chloro-6-fluoroquinoline-3-carboxylateHCID 178515184HCID 178515184, compound

Product 1

HCID 178515196HCID 178515196, compound

Procedure

The title compound was prepared following the procedure described in Step 3 of the synthesis of 4a, using 3b and phenyl hydrazine. 1H NMR (DMSO-d6) δ (ppm): 7.16 (1H, t, J=13.67 Hz), 7.41 (2H, t, J=7.56 Hz), 7.55 (1H, dt, J=8.54, 2.93 Hz), 7.77 (1H, dd, J=9.27, 4.88 Hz), 7.90 (1H, dd, J=9.27, 2.93 Hz), 8.18 (2H, dd, J=7.58, 1.95 Hz), 8.73 (1H, s). m/z 280.5 (MH+).

Sources & evidence

ORD record
ord-b6d4fbd1a61d466eae56dae3e2918e59
Source dataset
uspto-grants-2011_01
Patent number
US07863266B2

Reaction notes

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