反应详情

To a stirred solution of equimolar amount of 2-(2-hydroxy-ethylamino)-ethanol and dimethylcarbonate in ethanol (10 mL/g) was added 0.1 eqv. of sodium ethoxide. The mixture thus obtained was refluxed for 3 h and cooled. The mixture was concentrated, then dissolved in dichloromethane. It was then passed through a short pad of silica gel, washed with ethylacetate successively and concentrated to obtain 3-(2-hydroxy-ethyl)-oxazolidin-2-one as colorless oil. The product was used without further purification.

1. customThe mixture thus obtained
2. temperaturewas refluxed for 3 h
3. temperaturecooled
4. concentrationThe mixture was concentrated
5. dissolutiondissolved in dichloromethane
6. washwashed with ethylacetate successively
7. concentrationconcentrated