反应详情

温度

40 °C

7-Benzyl-3,7-dihydro-1H-purine-2,6-dione (5.0 g, 21 mmol) was mixed with sodium carbonate (3.3 g, 31 mmol) and 1-iodopentane (4.0 mL, 31 mmol) in DMF (60 mL). After being stirred at 40° C. for 18 h, the reaction mixture was diluted with water and EtOAc. The aqueous layer was extracted with EtOAc twice. The combined organic layers were dried, filtered and concentrated. The resulting white solid was collected and dried in vacuum oven at 50° C. for 18 h to provide the desired product (2.84 g, 44% yield). LCMS calculated for C17H21N4O2(M+H): 313.2. found: 313.2.

1. extractionThe aqueous layer was extracted with EtOAc twice
2. customThe combined organic layers were dried
3. filtrationfiltered
4. concentrationconcentrated
5. customThe resulting white solid was collected
6. customdried in vacuum oven at 50° C. for 18 h