反应详情

A solution of methyl 2-chlorobenzoxazole-4-carboxylate (1.0 g, 4.7 mmol) and thiomorpholine (1.4 mL, 14 mmol) in THF (20 mL) was stirred at ambient temperature for 1 h. Then, the reaction mixture was poured into EtOAc (100 mL) and washed with 1N HCl (20 mL), H2O (20 mL), brine (20 mL), dried (Na2SO4) and concentrated under reduced pressure. Purification by chromatography (silica gel, 5 to 50% EtOAc in hexanes) gave methyl 2-thiomorpholinobenzoxazole-4-carboxylate (1.1 g, 84%) as a yellow solid. 1H NMR and MS consistent.

1. washwashed with 1N HCl (20 mL), H2O (20 mL), brine (20 mL)
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated under reduced pressure
4. customPurification by chromatography (silica gel, 5 to 50% EtOAc in hexanes)