Lithium iodide → HCID 66874398, compound

HRID 249924Notes

Reaction equation

HRID 249924 reaction equation
[I-].[Li+:2].[CH3:3][C@H:4]1[CH2:9][NH:8][CH2:7][C@H:6]([CH3:10])[N:5]1[C:11]1[O:12][C:13]2[C:14](=[C:16]([C:20]([O:22]C)=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:15]=1>N1C=CC=CC=1>[CH3:3][C@H:4]1[CH2:9][NH:8][CH2:7][C@H:6]([CH3:10])[N:5]1[C:11]1[O:12][C:13]2[C:14](=[C:16]([C:20]([O-:22])=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:15]=1.[Li+:2]

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 66873655HCID 66873655, compound

Product 1

HCID 66874398HCID 66874398, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of lithium iodide (185 mg, 1.38 mmol) in refluxing anhydrous pyridine (10 mL) was added methyl 2-((2S,6S)-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate (100 mg, 0.346 mmol) and the reaction mixture was refluxed for 24 hours. The mixture was cooled to room temperature, concentrated to dryness and dried in vacuo to provide lithium 2-((2S,6S)-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate as a solid which was used without further purification: MS consistent

Workup

  1. temperaturethe reaction mixture was refluxed for 24 hours
  2. concentrationconcentrated to dryness
  3. customdried in vacuo

Sources & evidence

ORD record
ord-0aca13b455914ac3a2a32de03a3fcb58
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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