反应详情

5-(4-Methoxy-1H-indol-3-ylmethylene)-2,2-dimethyl-[1,3]dioxane-4,6-dione (0.392 g) was dissolved in dry THF (15 ml) and added slowly to cyclohexyl-magnesium bromide (10 ml, 1M) at room temperature with stirring. The reaction was stirred for 20 minutes, and then was worked up by the careful addition of saturated ammonium chloride solution, acidified with dilute HCl, and extracted with ethyl acetate. The crude product was purified on silica gel. Elution was done with 3:7 ethyl acetate-hexane to afford 0.390 g of 5-[cyclohexyl-(4-methoxy-1H-indol-3-yl)-methyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione.

1. stirringThe reaction was stirred for 20 minutes
2. extractionextracted with ethyl acetate
3. customThe crude product was purified on silica gel
4. washElution