反应详情

To a solution of 3-(7-methoxy-indol-1-yl)-3-pyridin-3-yl-propionic acid methyl ester (0.290 g) in THF (10 ml) was added a solution of lithium aluminum hydride (1 M in THF, 1 ml) at 0° C. The reaction mixture was stirred for 2 hours at room temperature. To the solution was added sodium sulfate decahydrate (1 g) and stirring was continued until no more bubbling was observed. The suspension was filtered through Celite and the filtrate was evaporated to dryness. The residue was purified by chromatography on silica gel eluting with ethyl acetate to give 3-(7-methoxy-indol-1-yl)-3-pyridin-3-yl-propan-1-ol (0.178 g) as an oil, (M+H=283).

1. stirringstirring
2. customno more bubbling
3. filtrationThe suspension was filtered through Celite
4. customthe filtrate was evaporated to dryness
5. customThe residue was purified by chromatography on silica gel eluting with ethyl acetate