反应详情

To a solution of [3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazol-4-yl]-methanol (1.14 g, 4 mmol) in THF (20 mL) is added PBr3 (0.76 mL, 8 mmol). The reaction mixture is stirred at reflux for 30 minutes. The reaction mixture is diluted with EtOAc and is washed with 0.2 N HCl. The organic layer is separated, dried (MgSO4), filtered, and concentrated to give the title compound as an oil.

1. temperatureat reflux for 30 minutes
2. washis washed with 0.2 N HCl
3. customThe organic layer is separated
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated