反应详情

A mixture of 5-bromo-1H-indole-3-carboxylic acid methyl ester (200 mg, 0.787 mmol), potassium carbonate (100 mg, 0.394 mmol) and DMF (1 mL) is stirred at room temperature and iodomethane (30 μL, 0.47 mmol) is added. After 1.5 hours, additional iodomethane (10 μL) is added and the reaction is stirred for 30 minutes and diluted with dichloromethane and filtered. The filtrate is concentrated under high vacuum, diluted with ethyl acetate, filtered and concentrated under reduced pressure to give the title compound (1105 mg, 99%). ES/MS m/e 270.0 (M+2).

1. stirringthe reaction is stirred for 30 minutes
2. filtrationfiltered
3. concentrationThe filtrate is concentrated under high vacuum
4. additiondiluted with ethyl acetate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure