反应详情

To 6-chloro-2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid benzyl ester (49, 6.00 g, 15.6 mmol) in tetrahydrofuran (100 mL) was added 1.0 M aqueous potassium hydroxide (100 mL). The reaction was heated to reflux overnight. The reaction was poured into water, acidified to pH 2 with 1 N hydrochloric acid and extracted with ethyl acetate. The organic portion was dried over anhydrous sodium sulfate, filtered and concentrated to give a white solid 115 (3.95 g, 85.8%).

1. temperatureThe reaction was heated
2. temperatureto reflux overnight
3. extractionextracted with ethyl acetate
4. dry with materialThe organic portion was dried over anhydrous sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated