反应详情

温度

98 °C

To a mixture of 3-(4-chloro-benzyloxy)-2-hydroxy-benzaldehyde (110 mg, 0.42 mmol), potassium carbonate (150 mg, 1.1 mmol) in acetonitrile (8 mL) was added iodoethane (0.2 mL, 2.5 mmol) at room temperature. The mixture was stirred at 98° C. for 18 hours. The reaction mixture was poured into a solution of saturated ammonium chloride and was extracted with ethyl acetate. The organic layer was collected, washed with brine, and dried over magnesium sulfate. After removal of solvent, a light yellow solid was obtained (629, 116 mg, 95%).

1. extractionwas extracted with ethyl acetate
2. customThe organic layer was collected
3. washwashed with brine
4. dry with materialdried over magnesium sulfate
5. customAfter removal of solvent
6. customa light yellow solid was obtained (629, 116 mg, 95%)