反应详情

温度

110 °C

Add dioxane (7 mL) to a mixture of 3-phenyl-1H-pyrazole (2 g, 13.9 mmol), copper iodide (132 mg, 0.05 mmol) and potassium carbonate (555 mg, 4.2 mmol). Add 2-fluoroiodobenzene (1.94 mL, 16.6 mmol), trans-cyclohexyldiamine (0.35 mL, 2.78 mmol). Heat at 110° C. for about 18 hours. Cool to RT and filter through a silica gel pad eluting with ethyl acetate. Concentrate and purify (silica gel chromatography, eluting with hexane:ethyl acetate 84:16) to give the desired compound (36%).

1. temperatureCool to RT
2. filtrationfilter through a silica gel pad
3. washeluting with ethyl acetate
4. concentrationConcentrate
5. custompurify
6. wash(silica gel chromatography, eluting with hexane:ethyl acetate 84:16)