反应详情

温度

60 °C

2.35 mL (19.78 mmol, 1.1 eq) of benzyl bromide are added to a solution of 5.0 g (17.98 mmol, 1 eq) of methyl 3-hydroxy-4-iodobenzoate in 30 ml of methyl ethyl ketone in the presence of 5.0 g of potassium carbonate. The reaction medium is heated at 60° C. for 5 hours and then hydrolyzed with water and extracted with ethyl acetate. The organic phases are combined and the solvents are evaporated off. 6.9 g of methyl 3-benzyloxy-4-iodobenzoate in oil form are used in the following reaction without further purification.

1. extractionhydrolyzed with water and extracted with ethyl acetate
2. customthe solvents are evaporated off
3. custom6.9 g of methyl 3-benzyloxy-4-iodobenzoate in oil form are used in the following reaction without further purification