Iodoethane → HCID 67273584, compound

HRID 250890Notes

Reaction equation

HRID 250890 reaction equation
I[CH2:2][CH3:3].[CH2:4]([NH:11][C:12](=[O:34])[N:13]([C:15]1[CH:16]=[C:17]([C:21]2[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30])=[CH:23][C:22]=2[OH:33])[CH:18]=[CH:19][CH:20]=1)[CH3:14])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[CH2:2]([O:33][C:22]1[CH:23]=[C:24]([CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30])[CH:25]=[CH:26][C:21]=1[C:17]1[CH:18]=[CH:19][CH:20]=[C:15]([N:13]([CH3:14])[C:12]([NH:11][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[O:34])[CH:16]=1)[CH3:3]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 11582687Methyl 3-[3'-(3-heptyl-1-methylureido)-2-hydroxybiphenyl-4-yl]propanoate

Product 1

HCID 67273584HCID 67273584, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

In a manner similar to that of Example (25a), by reaction of 200 μL (2.46 mmol, 3 eq) of 1-iodoethane and 350 mg (0.82 mmol, 1 eq) of methyl 3-[3′-(3-heptyl-1-methylureido)-2-hydroxybiphenyl-4-yl]propanoate (prepared in Example 15f) in 6 ml of methyl ethyl ketone in the presence of 500 mg (3.61 mmol, 4.4 eq) of potassium carbonate at 80° C. for 5 hours, methyl 3-[2-ethoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]propanoate is obtained in oil form and is used in the following reaction without further purification.

Sources & evidence

ORD record
ord-8ed5437c82154623b09fa7b2a7ed7b06
Source dataset
uspto-grants-2011_01
Patent number
US07863332B2

Reaction notes

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