Piperazine → 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

HRID 251419Notes

Reaction equation

HRID 251419 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=1>C1COCC1>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 923422-Chloro-5-(trifluoromethyl)pyridine

Product 1

HCID 6676181-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Piperazine (1.2 g, 13.77 mM) was heated with 2-chloro-5-(trifluoromethyl)pyridine (0.5 g, 2.75 mmol) in THF (2 mL) for 2 hours. Subsequently the reaction mixture was poured onto crushed ice and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate and evaporated to furnish the required product.

Workup

  1. additionSubsequently the reaction mixture was poured
  2. customonto crushed ice
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with sodium bicarbonate
  5. customevaporated

Sources & evidence

ORD record
ord-cebb817858524cfd8add367f4f98994b
Source dataset
uspto-grants-2011_01
Patent number
US07863446B2

Reaction notes

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