反应详情

A mixture of 4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)phenol ax7 (5 g, 26 mmol, 1 eq), potassium carbonate (7.19 g, 52 mmol, 2 eq), and 1-bromo-3-chloropropane (2.8 ml, 29 mmol, 1.1 eq) in acetone (120 ml) is stirred at reflux for 36 h. The mixture is then concentrated; the residue is dissolved in dichloromethane, and washed with a saturated solution of aqueous ammonium chloride. The organic layer is dried over magnesium sulfate and concentrated under vacuum to obtain 2-[4-(3-chloropropoxy)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole ax10 as a white solid (6.75 g).

1. temperatureat reflux for 36 h
2. concentrationThe mixture is then concentrated
3. dissolutionthe residue is dissolved in dichloromethane
4. washwashed with a saturated solution of aqueous ammonium chloride
5. dry with materialThe organic layer is dried over magnesium sulfate
6. concentrationconcentrated under vacuum