Hydrochloric Acid → HCID 23715078, compound

HRID 251488Notes

Reaction equation

HRID 251488 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH3:29])[CH:8]=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:28])[CH:16]=[C:17]([NH:19][C:20]([C:22]3[N:23]([CH3:27])[CH:24]=[CH:25][N:26]=3)=[O:21])[CH:18]=2)=[O:13])[N:10]=1)=[O:5])C.[OH-].[Na+:31].Cl.C(O)(C)C>CO>[CH3:29][N:7]1[CH:8]=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:28])[CH:16]=[C:17]([NH:19][C:20]([C:22]3[N:23]([CH3:27])[CH:24]=[CH:25][N:26]=3)=[O:21])[CH:18]=2)=[O:13])[N:10]=[C:6]1[C:4]([O-:5])=[O:3].[Na+:31]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 14798Sodium HydroxideHCID 11632705HCID 11632705, compound

Product 1

HCID 23715078HCID 23715078, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

The compound 9 (3.0 g, 7.5 mmol) was dissolved in methanol (37.6 ml), mixed with aqueous solution of sodium hydroxide (37.6 ml, 7.89 mmol) and stirred for one hour at 50° C. After being cooled to a room temperature, the resulting solution was mixed with hydrochloric acid (1N) to reach pH 2.0, and then mixed with isopropylalcohol to give the white powder, which was then filtered to give the compound 10 (2.85 g, 94%).

Workup

  1. temperatureAfter being cooled to a room temperature
  2. customto give the white powder, which
  3. filtrationwas then filtered

Sources & evidence

ORD record
ord-b9dd2fc85d1244b9b370c7c0d64b10a3
Source dataset
uspto-grants-2011_01
Patent number
US07863455B2

Reaction notes

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